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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

N. V. Gottumukkala

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Open access Jul 2026

Genome-wide CRISPR Screening Reveals Cullin-1 as a Therapeutic Target Enhancing Efficacy of CD19-directed Immunotherapy

C Cullin-1 inhibition stabilizes CD19 surface expression, preventing its loss under immunotherapeutic pressure and improving the efficiency of CD19-targeting immunotherapies, thus arguing for potential incorporation of pevonedistat into novel combination therapies.

N. V. Gottumukkala, Tomáš Loja, M. Šmída · 0 citations

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