Author

N. Serale

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#protein folding Open access Sep 2026

Experimental characterization of zeta viruses and discovery of betaviroid-like RNAs expand the diversity of coding circular RNA replicons

Viroid-like RNAs (vdlRNAs) are infectious agents characterized by single-stranded circular genomes folding into compact secondary structures, often containing self-cleaving ribozymes involved in replication. Recent metatranscriptomic studies have expanded their diversity across multiple ecological niches and revealed n...

N. Serale, M. Chiumenti, P. Mussano et al. · bioRxiv · 0 citations

Open access Sep 2026

A newly established reverse genetic system for a circular RNA virus reveals new requirements for infection and its biocontrol potential

This work constructed the first infectious cDNA clone of an ambivirus, Fusarium graminearum ambivirus 1 (FgAV1), using a head-to-tail dimer placed downstream of a fungal promoter, demonstrating that FgAV1 infection triggers a fungal RNAi response, extending the antiviral role of host sRNAs to circular RNA viruses.

Yi Guo, M. Forgia, N. Serale et al. · Science Advances · 0 citations