N. Sayyed

Rufigallol attenuates splenic damage caused by STZ by targeting oxidative stress, inflammation, and the apoptosis pathway

Ameliorative Effect of Rosinidin Against an Ethanol-induced Ulcer: Molecular Docking and Implication of PGE2/ IL-6/IL-1β/TNF-α and NF-κB Pathways.

INTRODUCTION/OBJECTIVE In this study, we assessed the antiulcer property of rosinidin on the Ethanol (EtOH)-induced ulcer. METHODS EtOH was administered orally to induce ulcers in rats. The potency of rosinidin 10 and 20 (mg/kg) was evaluated under trial with EtOH-induced gastric ulcer (EtOH 1.5 ml/animal). After ind...

Acemannan as a potential therapeutic agent for cognitive impairment via modulation of cholinergic, oxidative, and inflammatory pathways: in vivo and in silico evidence

Hypophyllanthin Protects Against Alcohol-Induced Hepatotoxicity in Rats: Involvement of Oxidative Stress, Inflammatory Cytokines, Apoptosis, and Autophagy

Introduction Ethanol consumption is a primary global health concern, frequently leading to severe hepatic injury. The present study assessed the hepatoprotective effects of hypophyllanthin against ethanol-induced hepatotoxicity in rats. Methods A Wistar rats were randomly assigned into five groups (n=6/group): Group I...

Protective Effects of Cubebin on Neuroinflammation, Neurotransmitter Depletion, Mitochondrial Dysfunction, and Motor Disability in Parkinsonian Rats

Parkinson’s disease (PD) is an advanced neurodegenerative state with diverse degeneration of dopaminergic neurons, oxidative stress, mitochondrial dysfunction, and neuroinflammation. The present study aimed to evaluate the neuroprotective effect of cubebin against rotenone-induced Parkinsonism disability in Wistar rats...

Aloesin mitigates cisplatin-induced nephrotoxicity by suppressing NF-κB-mediated oxidative stress and modulating Bax/Bcl-2/caspase pathways.

Ameliorative effect of rufigallol on cisplatin-induced nephrotoxicity in rats: biochemical and histopathological evaluation.

Study results indicate that rufigallol may protect against cisplatin-induced nephrotoxicity; however, additional research is needed to confirm its effectiveness in humans.

Erucic acid arbitrates neuroprotection in streptozotocin-induced memory deficit via improving oxidative stress/neuroinflammatory indicators/cholinergic activity in rodents.

BACKGROUND Erucic acid (EA), a monounsaturated omega-9 fatty acid derived from Raphanus sativus L. seeds, has antioxidant and anti-inflammatory properties. This study investigated its neuroprotective effects against streptozotocin (STZ)-induced diabetes-associated cognitive dysfunction in rats. METHODS Male Wistar ra...