Author

N. Salakhutdinov

3 papers indexed here

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2027

Synthesis, crystal structure, pharmacophore analysis and molecular docking of monoterpene-isatin conjugates as potential SARS-CoV-2 PLpro ligands with in vitro antiviral evaluation

A series of novel conjugates combining monoterpenoid fragments (camphor, fenchone) with an isatin scaffold was designed as potential SARS-CoV-2 PLpro inhibitors. Molecular docking and pharmacophore analysis confirmed their ability to bind to the active site of PLpro. Single crystal of target compound 12 was grown, the...

V. Oreshko, S. Borisevich, K. Kovaleva et al. · Журнал структурной химии · 0 citations

Sep 2026

N-(3'-(Dimethylamino)propyl)amides based on 18βH-glycyrrhetinic acid retain P-glycoprotein inhibitory and MDR-reversing activities.

Multidrug resistance (MDR) is a major obstacle to successful cancer chemotherapy, primarily mediated by P-glycoprotein (P-gp/ABCB1), which actively effluxes structurally unrelated anticancer drugs. We previously reported Sol-DMAP, an 18βH-glycyrrhetinic acid-derived P-gp inhibitor that reverses chemoresistance and exhi...

A. Moralev, Nika V. Konoreva, O. Salomatina et al. · Biochemical and Biophysical... · 0 citations

Aug 2026

Design, synthesis, and structural characterization of covalent tetrahydroquinoline-based inhibitors of coronavirus 3CLpro.

These findings establish substituted tetrahydroquinolines as a viable scaffold for the development of broad-spectrum anticoronaviral agents and establish a promising in vivo safety profile.

A. A. Pronina, D. Shcherbakov, A. P. Sanchez-Pimentel et al. · Bioorganic chemistry (Print) · 0 citations