Women of African ancestry experience disproportionately aggressive breast cancer (BC) and poorer survival yet remain substantially underrepresented in cancer genomic studies. Consequently, the contribution of inherited genetic ancestry to breast tumor biology remains poorly understood. To address this gap, we lev...
Rachel Martini, William Hooper, Timothy R. Chu et al.· Cancer Epidemiology, Biomark...· 0 citations
AI and deep learning have transformed single-cell transcriptomics, empowering unsupervised annotation, trajectory inference, and cross-dataset integration at scale. Here, we propose bulk RNA-seq deconvolution as a novel task for single-cell foundation models. Deconvolution estimates cell type proportions from bulk RNA-...
Ali Oku, Heather Geiger, N. Robine et al.· bioRxiv· 0 citations
A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.
Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al.· Nature· 7 citations
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