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Author

N. R. Prasad

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2 papers indexed here

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Open access Sep 2026

Tryptoline urea derivatives for sensitizing resistant breast cancer cells to doxorubicin.

Co-administration of compound 9 with doxorubicin (DOX) significantly reduced fold resistance in MCF-7/DXR cells, almost restoring their sensitivity to levels similar to the parental cell line, and compound 9 acted synergistically with DOX, markedly increasing its cytotoxicity, associated with a strong increase in apopt...

Filipa Barbosa, Karankumar Balamurugan, N. R. Prasad et al. · 0 citations
Sep 2026

Ebselen sensitizes multidrug-resistant cancer cells to doxorubicin by disrupting cellular redox homeostasis and inducing ferroptosis.

AIM Multidrug resistance (MDR), driven by P-glycoprotein (P-gp/ABCB1)-mediated drug efflux and enhanced antioxidant defenses, remains a major obstacle to effective chemotherapy. This study investigated whether thioredoxin reductase (TrxR) inhibition by ebselen induces ferroptosis, suppresses NRF2/Keap1 signaling and re...

S. Baskar, S. Anbiah, N. R. Prasad · 0 citations

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