Validation of Aptamer–Protein Interactions by Biolayer Interferometry: A Study of 88 Candidate Molecules
An aptamer’s low mass confines the label-free response to hundredths of a nanometer, where artifacts mimic binding yet yield computable dissociation constants. To define and test a priori criteria distinguishing binding from artifact, 88 computationally designed aptamers against seven human proteins were studied by bio...
E. Ershova, N. Pozdnyakova, A. Egorshina et al.
· International Journal of Mol... · 0 citations