Jul 2026
TCR-Associated Rasal1 rewires T-cell mitochondrial metabolism to regulate checkpoint immunotherapy 2267535
It is demonstrated that Rasal1 selectively regulates mitochondrial oxidative phosphorylation (OXPHOS) metabolism, while cooperating with anti—PD—1 therapy to limit T-cell exhaustion and promote the expansion of CD8+PD-1+TCF1+ stem-like progenitor cells, leading to enhanced tumor control.
N. Ponnoor, Chen Liu, David Papadopoli et al.
· Journal of Immunology · 0 citations