Surface chemistry governs sex-dependent responses to PEG and zwitterionic siRNA nanocarriers in primary macrophages
Nanoparticle carriers are widely used for nucleic acid delivery, with poly(ethylene glycol) (PEG)–conjugated nanoparticles emerging as a frontrunner in the field. Growing concerns surrounding PEG immunogenicity have generated interest in zwitterionic polymers as alternative biocompatible surface grafts. At present, the...