Author

N. Ohno

2 papers indexed here

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Open access Sep 2026

Synaptic Mitochondrial Oxidative Stress Contributes to Individual Variability in Age‐Related Cognitive Inflexibility in Mice

Aging is associated with impairments in cognitive flexibility, a key executive function supported by the medial prefrontal cortex (mPFC), yet the biological mechanisms underlying individual variability in age‐related decline remain poorly understood. Here we investigated behavioral, ultrastructural, and proteomic corre...

Rui Yamada, H. Nagai, C. Numa et al. · Aging Cell · 0 citations

Open access Aug 2026

Artificial hibernation reveals synaptic engram architecture associated with memory retention.

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal representations after memory formation suggest alternative possibilities. To elucidate the structural trace underlying memory re...

Y. J. Lin, A. Takahashi-Nakazato, K. Tsutsumi et al. · Science · 1 citation