N. Mechawar

Disease-specific tangle immunophenotypes distinguish hippocampal vulnerability in Alzheimer’s disease and Parkinson’s disease dementia

INTRODUCTION Tau pathology typically occurs in Alzheimeŕs disease (AD), however is also frequently present in Parkinsońs disease dementia (PDD) and Dementia with Lewy Bodies (DLB), yet its disease-specific signature is unclear. METHODS Five tau, amyloid-β, α-synuclein and neuronal markers were analysed across hippocamp...

T2 relaxometry for myelin water fraction: an ex vivo brain imaging study

Introduction Myelin water imaging provides a non-invasive approach for indirectly investigating myelin content of the brain by magnetic resonance Imaging (MRI). Myelin water fraction (MWF) reflects the fraction of water signal associated with water trapped between myelin layers. Postmortem imaging provides a unique opp...

miR-151a-5p in Neuron-Derived Extracellular Vesicles Mediates Antidepressant Response

Major depressive disorder (MDD) lacks accessible molecular markers that reflect brain pathology and monitor treatment response. Using the neuron-specific protein SNAP25, we investigated the cargo of neuron-derived extracellular vesicles (NEVs) isolated from plasma in relation to antidepressant treatment and identified...

Reconciling the neurogenic hypothesis of depression with recent advances in adult hippocampal neurogenesis research in humans.