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Author

N. M. Arulmozhi

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Review Sep 2026

Structure-Based Design Strategies for Coumarin-Derived CDK4 Inhibitors in Non-Small Cell Lung Cancer: Current Progress and Therapeutic Perspectives

Current evidence suggests that enhanced CDK4 selectivity and rational combination strategies may improve the therapeutic index in NSCLC and coumarin-based scaffolds are promising platforms for CDK4-targeted drug development.

N. M. Arulmozhi, Thiyagarajan Gopal · 0 citations
Jul 2026

Structure-Based Design and Evaluation of Coumarin-Derived CDK4 Inhibitors for Non-Small Cell Lung Cancer: An Integrated Computational Study.

Findings establish coumarin-derived scaffolds as promising starting points for the development of next-generation CDK4-targeted therapeutics and provide a strong computational foundation for future experimental validation in NSCLC.

N. M. Arulmozhi, Thiyagarajan G · 0 citations

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