N. M. Ahmed

Efflux pump gene ABCA as targets for deep learning-based de novo inhibitors in invasive aspergillosis caused by Aspergillus fumigatus.

This study aims to design and evaluate novel therapeutic binders targeting the ATP-binding region of the AbcA efflux transporter protein in Aspergillus fumigatus. By inhibiting ATP binding, these binders seek to prevent AbcA-mediated azole resistance and restore the effectiveness of antifungal treatments. The research...