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Author

N. Lambert

2 papers indexed here

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Open access Sep 2026

G protein diffusion states reveal receptor binding dynamics at single-molecule scale

It is suggested that native GPCR-G protein interactions are not resolved at 15 ms time resolution and a diffusion-based approach is established for studying receptor-G protein kinetics in living cells.

Signe Mathiasen, Jozsef Meszaros, Chase M. Webb et al. · 0 citations
Open access Sep 2026

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

Phospholipase C β (PLCβ) enzymes are activated by heterotrimeric G protein subunits, increasing hydrolysis of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) at the plasma membrane. All four human PLCβ isoforms (PLCβ1–4) are activated by Gαq, whereas PLCβ1–3 are activated to varying extents by Gβγ. The binding sites...

Isaac J. Fisher, Kanishka Senarath, Kennedy Outlaw et al. · 0 citations

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