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N. Kyrpides

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#large language models Open access Sep 2026

Coevolutionary mining of prokaryotic non-coding elements with a genome language model

Microbial genomes encode non-coding RNAs (ncRNAs) and nucleic-acid-interacting proteins essential to biology and biotechnology. However, discovery of these systems remains protein-centric and based on similarity to known sequences. Here, we introduce Minerva, a framework for coevolutionary mining that uses genome langu...

David B. Li, G. Brixi, Alexandra S. Kim et al. · 1 citation
Open access Sep 2026

Discovery of novel enzybiotic candidates targeting human bacterial pathogens through large-scale viral-host profiling

The rise of antibiotic-resistant bacteria demands alternative therapeutic strategies, with bacteriophage (phage) therapy and phage-derived enzybiotics emerging as promising approaches. However, identifying candidate phages against specific pathogens has historically been a bottleneck due to the need for cultivation met...

Mateus B. Fiamenghi, N. Kyrpides · 0 citations

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