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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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N. Hatano

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Aug 2026

Direct Tumor Suppression by Anti-Basigin Antibody and Enhancement of Macrophage-Mediated Cancer Cell Phagocytosis under SIRPα Blockade

The transmembrane protein CD47 expressed on tumor cells suppresses Fcγ receptor–mediated antibody-dependent cellular phagocytosis (ADCP) through its interaction with signal regulatory protein α (SIRPα), a transmembrane protein expressed on phagocytic cells such as macrophages. Although blockade of the CD47–SIRPα intera...

Yi-Yan Yang, Tomoko Takai, N. Hatano et al. · 0 citations

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