Spatially restricted iron-metabolism-associated stress programs prime invasive mesenchymal glioblastoma states in human tissue-context models.
BACKGROUND Glioblastoma (GBM) recurrence is driven by invasive tumor cells that infiltrate surrounding brain tissue and evade surgical and therapeutic eradication. While dysregulated iron handling is a well-recognized feature of malignant cancers, its contribution to invasive GBM cell states in the physiological contex...