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Author

N. Gascoigne

2 papers indexed here

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Jul 2026

RGS16 as a Therapeutic Target to Overcome TGFβ-Induced Resistance in Adoptive T Cell Therapies 2250696

T cells, particularly CD8+ T cells, play a central role in immune defense against intracellular pathogens and in tumor immunosurveillance. However, within tumors, these cells often become functionally exhausted, limiting the effectiveness of T cell—based immunotherapies. To maintain self-tolerance and immune home...

A. Musah, Liang-Zhe Wu, Edem Bokoe et al. · 0 citations
Open access Jul 2026

Targeting NOX1 to Reprogram T Cell Activation and Metabolism for Enhanced CAR T Efficacy 2251163

T-cell exhaustion is a critical roadblock to achieving durable remission with adoptive cell therapies. The immunosuppressive tumor microenvironment limits T-cell persistence and function, demanding new reprogramming techniques. Our genome-wide CRISPR screen in CD8+ T cells identified NOX1 as a novel, negative eff...

Edem Bokoe, A. Musah, V. Tan et al. · 0 citations

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