Open access
Oct 2026
APOE4 allele modifies the effect of lifestyle interventions on cognition
The apolipoprotein E ε4 allele (APOE4) is the main genetic risk factor for incidence and earlier onset of dementia, and APOE4 carriers are thus considered a key target group for dementia risk reduction. APOE4 carriership also impacts the association between lifestyle and cognitive decline. Our meta-analysis inves...
J. Lehtisalo, Ari Solomon, E. Levälahti et al.
· Communications Medicine · 0 citations