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ClinMPO improved performance across two complementary schemes covering ICD-11 diagnostic categories and psychiatric practice competencies and Blinded assessment by three clinicians showed improved rationale quality across CPTS criteria.
Out-of-distribution evaluation showed broadly similar patterns, supporting the promise of multimodal AI for predicting RBD in MDD and identifying interpretable potential digital markers of prodromal synucleinopathy.
Gut microbiome provides a candidate approach for potential risk stratification in psychiatric populations, and MDD + RBD may represent a biologically distinct depression subtype associated with potential neurodegenerative risk.
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