Author

N. Beschorner

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Open access Oct 2026

Single-domain antibody-conjugated lipid nanoparticles for selective mRNA delivery to CD4⁺ T cells and Brec1-mediated excision of HIV-1 proviral DNA

Approaches to curing HIV infection aim to eliminate the latent viral reservoir — long-lived, resting CD4⁺ T cells harboring integrated but transcriptionally silent proviral DNA — which persists despite effective antiretroviral therapy. The HIV-1 LTR-specific designer-recombinase Brec1 can precisely excise integrated pr...

Melanie Wittner, P. Hartjen, Oliver Keil et al. · Scientific Reports · 0 citations

Open access Sep 2026

Development of a Recombinant Adeno-Associated Virus Vector for Human T Lymphocyte- and Natural Killer Cell-Targeted Gene Therapy.

A CD7-targeted rAAV vector featuring a nanobody-fused hybrid capsid derived from a rationally selected chimeric combination of AAV6 and AAV9 establishes an integrated capsid-genome design framework for targeting human T and NK cells, notoriously challenging immune cell populations for gene therapy, and provides a versa...

H. Jahnz, M. V. Hamann, H. Kim et al. · Human Gene Therapy · 0 citations

Open access Aug 2026

Development of an investigational medicinal stem cell gene therapy product to attempt curing human immunodeficiency virus infection

This work proposes to test an alternative strategy, namely expression of a designer recombinase which specifically excises HIV provirus from the genome under a Tat-inducible promoter so that expression is restricted to infected cells.

Laura Weigand, S. Herkt, Maike Voges et al. · Scientific Reports · 0 citations