Emerging analytical techniques for tamoxifen and metabolite quantification in diverse matrices.
Tamoxifen (TMX), a key selective estrogen receptor (ER) modulator used in hormone-dependent breast cancer therapy, undergoes extensive metabolism to produce active metabolites, including endoxifen (END), 4-hydroxytamoxifen (4HT), and N-desmethyltamoxifen (NDT). The simultaneous determination of these compounds across p...