Entresto attenuates dexamethasone-induced metabolic dysfunction-associated steatotic features in rats: role of potential SGK1/FOXO3a regulatory pathway and cardio-metabolic axis
Prolonged or high dexamethasone (DEXA) exposure can promote steatohepatitis-like liver injury through insulin resistance, oxidative stress, inflammation, mitochondrial dysfunction, and fibrosis. Sacubitril/valsartan (Entresto) exhibits metabolic, anti-inflammatory, and antifibrotic properties that may protect again...