Optimization and evaluation of curcumin-loaded zein microneedles for potential treatment of melanoma.
The membrane damage of melanoma cells, measured by lactate dehydrogenase (LDH) assay, further supported the cytotoxic effect of Cur-ZMNs against treated cells, while showing no toxic effect against normal fibroblasts, indicating the potential of prepared Cur-ZMNs for effective treatment of melanoma.