Author

Mustafa N. Abbas

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Open access Aug 2026

TOMOC: a topology-driven multi-objective evolutionary framework for robust overlapping protein complex detection in noisy PPI networks

Protein complexes constitute fundamental functional modules within cells and play a crucial role in regulating many biological processes. Detecting protein complexes from protein-protein interaction (PPI) networks has therefore become a central problem in computational systems biology. However, many existing computatio...

Mustafa N. Abbas, David Broneske, G. Saake · BMC Bioinformatics · 0 citations

Open access Jul 2026

TF-MOEA$^{+}$: A Multi-Objective Evolutionary Framework with Self-Adaptive Topological-Functional Mutation for Protein Complex Detection.

TF-MOEA, a multi-objective evolutionary framework built on NSGA-II and equipped with two biologically informed search operators, consistently outperforms all baseline methods considered in this study in both detection accuracy and functional relevance.

Mustafa N. Abbas, David Broneske, Gunter Saake · IEEE transactions on computa... · 0 citations