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Author

Mukesh Chandra Sharma

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Review Oct 2026

Recent Advances in Pharmacological Interventions for Huntington's Disease: Evidence from Clinical Translation.

Huntington's Disease (HD) is a rare autosomal dominant neurodegenerative disorder characterized by progressive motor dysfunction, psychiatric disturbances, and cognitive decline. An expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene causes it to repeat, leading to the production of mutant Huntingtin Protein...

V. Raj, M. Gupta, Neerja Kumari et al. · 0 citations
Review Aug 2026

Exploring the Therapeutic Potential of Bioactive Peptides in Modulating Tau Protein Interactions via the PI3K/Akt Pathway in Neurodegenerative Diseases.

Neurodegenerative Diseases (NDs) represent a growing global health challenge, characterized by progressive neuronal loss and cognitive decline. Central to these disorders are tauopathies, characterized by abnormal aggregation and hyperphosphorylation of tau proteins, leading to synaptic dysfunction and neuronal degener...

Kuldeep Singh, Shiv Narayan, Pranshul Sethi et al. · 0 citations
Review Jul 2026

Integrative Phytotherapy for Neurodegenerative Disorders: Bridging Traditional Botanicals, Bioactive Compounds, and Nanotechnology.

The synthesis of emerging evidence regarding the neuroprotective efficacy of phytotherapy is presented in this review, and the focus is on such traditional medicinal plants as Bacopa monnieri, Withania somnifera, and Centella asiatica.

Shatrudhan Prajapati, Shikha Yadav, A. Singh et al. · 0 citations
Review Jul 2026

Emerging Pharmacological Therapies for Huntington's Disease: Translational Insights from Recent Clinical Trials.

Key therapeutic approaches discussed include gene-silencing technologies such as antisense oligonucleotides, RNA interference, and CRISPRCas9- based strategies, as well as small-molecule modulators targeting mutant huntingtin aggregation, proteostasis, autophagy, mitochondrial dysfunction, and neuroinflammation.

B. Semwal, Kuldeep Singh, Ritesh Sharma et al. · 0 citations

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