Mujeeb A. Wakeel

Shape Shifting Proteusin Peptides and Their Multimodal Binding Interactions Underlie RiPP Biosynthesis

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are produced through the selective recognition and enzymatic modification of precursor peptides. While canonical RiPP leader peptides are generally short and unstructured, the discovery of nitrile hydratase-like leader peptides (NHLPs) has rev...

Tertiary structure of a Nif11-like leader peptide mediates protein-protein interactions with a RiPP biosynthetic enzyme

Photoreactive Pantetheinyl Mimics Reveal Design Limitations for Crypto‐Acyl Carrier Proteins

Polyketide synthases (PKS), fatty acid synthases (FAS), and non‐ribosomal peptide synthetases (NRPS) span a variety of protein architectures and catalytic modalities. Common to all these biosynthetic modalities is the centrality of a phosphopantetheinylated carrier protein, which shuttles substrate either inter‐ or int...