AF-RECAL: Multi-Modal Structural Recalibration of AlphaFold 3 Hallucinations in Intrinsically Disordered Human Disease Targets
AlphaFold 3 (AF3) has transformed structural bioinformatics through generative diffusion modeling of biomolecular assemblies. However, intrinsically disordered regions (IDRs)—which comprise over 30% of the human proteome and mediate essential cell signaling, oncogenesis, and phase separation—violate the classic thermod...