Mu Yang

METTL16 maintains photoreceptor integrity via splicing fidelity, mRNA stability, and translational regulation.

INTRODUCTION N6-methyladenosine (m6A) RNA modification is essential for retinal homeostasis. Pathogenic mutations in U6 snRNA have recently been identified in families with retinitis pigmentosa (RP), underscoring the importance of precise RNA processing in photoreceptor survival. METTL16 installs m6A at A43 of U6 snRNA...