Author

Mu-Chen Li

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Review Open access Oct 2026

Multi‐omics integration driving precision medicine in non‐small cell lung cancer: From molecular mechanisms to clinical translation

The molecular heterogeneity and therapeutic resistance of non‐small cell lung cancer (NSCLC) remain significant clinical challenges. In recent years, the integration of multi‐omics technologies has driven a paradigm shift in NSCLC research, evolving from static bulk sequencing to dynamic evolutionary tracking and...

Yuang Gao, Li-Yan Lin, Hong-Rui Zhou et al. · Clinical and Translational D... · 0 citations

Sep 2026

Nucleolar METTL16 drives ccRCC tumorigenesis and pazopanib resistance via translational activation of JAG1/Notch signaling pathway.

Resistance to tyrosine kinase inhibitors (TKIs), particularly pazopanib, is the primary driver of treatment failure in patients with advanced clear cell renal cell carcinoma (ccRCC). However, the epitranscriptomic mechanisms underlying TKI resistance, especially the regulatory role of N6-methyladenosine (m6A) modificat...

Zi-Xuan Gong, Ke-Qin Dong, Wen-Jin Chen et al. · Drug resistance updates · 0 citations