A unified physics‑based framework for macromolecular refinement , Predictor and mutational scanning. Built around a novel Self‑Organised Criticality (SOC) controller, it refines proteins, DNA, RNA, and their complexes using a fully differentiable energy function powered by OpenMM, then scales to thousands of in silico mutations across multiple GPUs — all without writing a single line of CUDA C++. And De Novo Protein Design , CRISPR-Cas Development (Design) And Chips Design (Classic , Quantum)
Mr.PAI And Mrs.Yoon A (Mei Mei) (美美) / Yoon A Limsuwan· Zenodo (CERN European Organi...· 0 citations
Evolution ONE is a standalone, vendor‑neutral platform that models cancer progression through the lens of Self‑Organised Criticality (SOC), duon biology, and physics‑based structural refinement. It ingests genomic mutation data (MAF, VCF) and outputs a complete oncological profile: the evolutionary regime of the tumour (stable, critical, or collapsing), future escape mutations likely to destabilise key proteins, CRISPR‑Cas editing designs with scored gRNA and off‑target search, epigenetic targets for methylation editing, personalised drug and stabiliser recommendations, correlations between lifestyle factors and mutation load. The engine can operate entirely on its own, or optionally leverage REAL FOLD ONE and REAL FOLD ONE HT for atomic‑resolution ΔΔG calculation and high‑throughput mutation scanning. EVOLUTION ONE is a high-performance, fully differentiable translational medicine platform modified for predictive epidemiology and viral evolutionary dynamics. By pivoting its core mathematical architecture from oncological mutation modeling to viral pathogen tracking, the engine bypasses traditional probabilistic frameworks in favor of a deterministic, sub-quantum variable approach. Powered by Structural Calculus and multi-scale physics engines, EVOLUTION ONE models the transition of infectious diseases from localized outbreaks to global pandemics as structural phase transitions, while simultaneously forecasting viral antigenic drift and immune escape vectors before they manifest in the wild. Evolution ONE — Standalone Ageing & Longevity Engine A production-grade, 100% differentiable PyTorch framework for biological age trajectory estimation, higher-order tissue entropy modeling, and non-explosive cellular rejuvenation optimization.
Mr.PAI And Mrs.Yoon A (Mei Mei) (美美) / Yoon A Limsuwan· Zenodo (CERN European Organi...· 0 citations
A unified physics‑based framework for macromolecular refinement , Predictor and mutational scanning. Built around a novel Self‑Organised Criticality (SOC) controller, it refines proteins, DNA, RNA, and their complexes using a fully differentiable energy function powered by OpenMM, then scales to thousands of in silico mutations across multiple GPUs — all without writing a single line of CUDA C++.
Mr.PAI And Mrs.Yoon A (Mei Mei) (美美) / Yoon A Limsuwan· Zenodo (CERN European Organi...· 0 citations
SUPER DNS ONE is a fully differentiable, three‑dimensional finite‑volume solver for the compressible Navier–Stokes equations. It is designed for high‑fidelity civilian research: Medical flows – cardiovascular haemodynamics, respiratory aerosol transport, micro‑fluidic drug delivery. Atmospheric and environmental physics – turbulent boundary layers, pollutant dispersion, cloud microphysics. Civil aviation – aerodynamic analysis, noise reduction, wake turbulence. Hypersonic civilian transport – real‑gas effects, shock capturing, high‑speed boundary‑layer transition. And More. This software is not intended, tested, or authorised for military applications, weapons development, or any form of armed conflict.
Mr.PAI And Mrs.Yoon A (Mei Mei) (美美) / Yoon A Limsuwan· Zenodo (CERN European Organi...· 0 citations
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