Review
Open access
Aug 2026
CAR T cell therapy beyond cancer: current status, challenges and future prospects
This review highlights how CAR-based strategies can be adapted across diverse disease settings by redirecting engineered immune responses toward disease-sustaining cellular compartments and position programmable cellular immunotherapy as a broadly adaptable platform for eliminating persistent pathological cells, remodeling diseased tissue environments, and restoring long-term immune homeostasis.
Saurabh Upadhyay, Sungwoo Cho, K. Upmanyu et al.
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