De novo design of protein antagonists of bacterial pathogen type III secretion system needle assembly
The rational design and characterization of functional T3SS needle binding proteins are reported, establishing a molecular blueprint for the design of functional T3SS needle binding proteins, enabling future efforts to disrupt conserved secretion systems underlying bacterial pathogenesis.
Ruo-Qing Jia, Jin-Kyo Jung, Aashi Inani et al.
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