Author

Monika K. Kawecka

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Open access Sep 2026

Stepwise pairing and fast transition regulated by recombination drive meiotic chromosome interactions

Maternal and paternal homologous chromosomes recognize each other and pair during meiosis to ensure accurate chromosome segregation. However, the mechanisms that drive chromosome pairing and their regulation remain poorly understood. To investigate this, we develop a fluorescence reporter-operator system based on the l...

L. P. de Almeida, V. M. Butler, Leandra Marín et al. · Nature Communications · 0 citations

Open access Sep 2026

RMI2 regulates recombination intermediate metabolism to ensure proper chromosome segregation in mammalian meiosis

Abstract Proper segregation of meiotic chromosomes depends on the controlled formation and resolution of recombination intermediates that give rise to crossovers (COs). While the BTRR complex—comprising the BLM helicase, topoisomerase IIIα, and the proteins RMI1 and RMI2—is a well-characterized regulator of recombinati...

L. P. de Almeida, Tolkappiyan Premkumar, Monika K. Kawecka et al. · Nucleic Acids Research · 0 citations