It is well known that both innate and adaptive immune systems in newborns are immature, making them highly susceptible to infection. Additionally, pre-term newborns with hindered immune systems are more prone to increased mortality and morbidity. Newborns are capable of mounting adaptive immune responses, but their cap...
A. Munteanu, M. Surcel, Elena-Georgiana Dobre et al.· Frontiers in Aging· 0 citations
Cutaneous melanoma remains one of the most challenging neoplasms and the deadliest form of skin cancer. miRNAs are a class of non-coding RNA molecules found in both tissues and body fluids that can negatively regulate gene expression in eukaryotic cells, playing key roles in health and disease. Dysregulated miRNA level...
Monica Neagu, Elena-Georgiana Dobre, C. Constantin· Frontiers in Immunology· 0 citations
This study found that GDCs exhibited high levels of costimulatory molecules, indicating a phenotypically mature state, but preserved the ability to respond to LPS (lipopolysaccharide) maturation stimuli by cytokine production, and cytokine secretion patterns observed in prime/ boost co-culture systems indicate the pote...
I. Ionescu, C. Țucureanu, R. Chelmuș et al.· PLoS ONE· 0 citations
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