Design and synthesis of metronidazole-substituted dihydropyrimidinones with biological evaluation and molecular docking studies
Metronidazole is a well-known Nitroimidazole drug with comprehensive antibacterial action. In this study, a series of novel Metronidazole-substituted 3,4-dihydropyrimidinones ( 3a–3j ) were synthesized via a modified Biginelli reaction to explore their potential as antibacterial agents. The newly synthesized comp...