Efficacy and Safety of Standard-Dose Direct Oral Anticoagulants Compared with Warfarin in Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Four Pivotal Randomized Controlled Trials
Atrial fibrillation (AF) is a major cause of thromboembolic stroke and cardiovascular morbidity. Large pivotal randomized controlled trials have evaluated direct oral anticoagulants (DOACs) against warfarin. To synthesize the efficacy and safety of standard-dose or principal higher-dose DOAC regimens compared with warf...