Triazine-Sulfonamide Hybrids: Synthesis, Antimicrobial Evaluation and In silico Investigation of their Potential Interaction with Dihydrofolate Reductase (DHFR)
Triazine–sulfonamide hybrids offer a versatile scaffold for antimicrobial drug, with the triazine core enabling structural modification and the sulfonamide group supporting target interactions. DHFR inhibition by these hybrids provides a rational strategy for developing new antimicrobial agents against the growing chal...