Preliminary gastroprotective effect of aqueous Bixa orellana leaf extract in an HCl/ethanol‑induced gastric ulcer rat model
Aqueous BOE showed a possible dose-related gastroprotective trend, with 150 mg/kg producing the most favorable numerical pattern, but larger dose-response studies with extract standardization, blinded morphometric assessment, ulcer-area and mucus endpoints, and biochemical assays are required before efficacy or mechani...