Development and Optimization of Baicalin-Loaded Transniosomes Using Quality by Design: Dermatokinetic and In Vivo Efficacy Evaluation.
OBJECTIVE This study aimed to develop and optimize a baicalin-loaded transniosomal gel (BCL-TN) to enhance the dermal delivery and therapeutic efficacy of baicalin for the management of skin cancer. SIGNIFICANCE Baicalin possesses potent anticancer activity but exhibits poor skin permeability, which limits its clinic...