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Author

Mohammed S. Taghour

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Sep 2026

Integrated in vitro and in silico evaluations of novel benzanilide derivatives as anticancer agents.

AIMS This study aimed to design, synthesize, and evaluate novel benzanilide derivatives as potential anticancer agents targeting VEGFR-2-mediated tumor angiogenesis. MATERIALS AND METHODS Eight benzanilide derivatives (7a-e, 9a-b, and 11) were synthesized and structurally confirmed using spectroscopic methods. The co...

A. Metwaly, Hazem Elkady, Walid E. Elgammal et al. · 0 citations
Open access Aug 2026

Integrated design, synthesis, biological evaluation, and computational mechanistic insights of novel benzanilide derivatives as VEGFR-2 targeted anticancer agents

Findings identify compound 7e as a promising VEGFR-2-targeted anticancer lead with strong enzymatic inhibition, potent cytotoxicity, and a well-supported mechanistic profile integrating experimental and computational evidence.

A. Metwaly, Walid E. Elgammal, I. Eissa et al. · 0 citations

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