AIMS
In this study, new 2,3,4,9-tetrahydro-1H-carbazol-1,3,4-oxadiazole-N-phenylacetamide hybrids 8a-n as potential dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for the treatment of Alzheimer's disease (AD) were introduced.
METHODS
The target compounds were designed using a molecula...
ABSTRACT In this study, we report the synthesis of 14 Biginelli adducts and the evaluation of their anticancer activity against three human cancer cell lines: MCF‐7 (breast), SW480 (colon), and Hep‐G2 (liver), as well as the noncancerous Hek‐293 cell line. Among the synthesized derivatives, compound 8n emerged as the m...
Aida Iraji, Sara M. Farid, Mohammadreza Eftekharian et al.· Chemistry and Biodiversity· 0 citations
A new series of compounds was evaluated as prospective in vitro antimalarial agents against the chloroquine‐sensitive 3D7 and chloroquine‐resistant K1 strains of Plasmodium falciparum, and the compound bearing a 4‐chloroaryl moiety was the most active against P. falciparum.
Lina Rezainia, M. Sayahi, Eisa Kaveh Vernousfaderani et al.· Chemistry and Biodiversity· 0 citations
Kinetic enzyme assays revealed that compound 9f acts as a competitive inhibitor of α-glucosidase, competing with the natural substrate for binding to the active site, with a Ki value of 100 nM, and pharmacokinetic predictions showed that compound 9f exhibits a bioavailability radar and drug-likeness profile similar to...
Shahab Kermaninia, M. Sayahi, Mohammad Halimi et al.· RSC Advances· 0 citations
Findings identify compound 9b as a promising lead α-glucosidase inhibitor with potent in vitro and in vivo antihyperglycemic activity, warranting further investigation for the treatment of type 2 diabetes.
Elika Salehi Ghalehsefid, Mohammad Halimi, Hassan Mohammadi et al.· European journal of medicina...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
