Molecular Regulation of Bone Remodeling in Osteoporosis and Current Therapeutic Approaches.
Osteoporosis arises from an imbalance in bone remodeling in which osteoclast resorption surpasses osteoblast activity. This process is regulated by the receptor activator of NF-κB ligand/receptor activator of NF-κB/osteoprotegerin system and Wnt/β-catenin signaling pathway, which are influenced by hormones, cytokines,...