Mohammad Javad Arayesh

Differential effects of amyloid-β and tau on UCH gene expression in Drosophila models of Alzheimer's disease.

BACKGROUND Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by progressive impairments in learning and memory. Substantial evidence indicates that dysfunction of the ubiquitin-proteasome system (UPS) in the AD brain leads to aberrant protein aggregation, ultimately resulting in synaptic dys...