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Author

Mohamed N. Fawzy

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Review Sep 2026

Resveratrol engages SIRT1/AMPK networks to restore BDNF signaling, autophagy, and mitochondrial function in age-related cognitive decline: A geroscience perspective.

Age-related cognitive decline and neurodegenerative disorders present significant challenges in neuropsychiatry, as current therapeutic strategies largely fail to adequately address the complexities of cerebral aging. Resveratrol, a natural polyphenol, has become a promising multi-target neuroprotective agent that can...

A. Al-Dhahi, Hayder M. Al-kuraishy, Mohamed N. Fawzy et al. · 0 citations
Review Sep 2026

Targeting the α7-nicotinic acetylcholine receptor in multiple sclerosis: Implications for immunomodulation and neuroprotection.

By integrating immunomodulatory and neuroprotective actions, α7-nAChR targeting represents a mechanistically compelling strategy for comprehensive disease modification in MS, although clinical translation remains contingent upon overcoming significant pharmacological and biomarker-related challenges.

A. Al-Dhahi, Hayder M. Al-kuraishy, Ahmed A. Mohamed et al. · 0 citations
Review Open access Jul 2026

Immunometabolic reprogramming in multiple sclerosis: from pathogenic amplifier to therapeutic target in neuroinflammation and remyelination

Multiple sclerosis (MS) has conventionally been considered a prototypical autoimmune disorder. While modern immunotherapies effectively control relapsing conditions, they fail to avert progressive neuroinflammation, neurodegeneration, and remyelination failure. This review offers an evidence-based recontextualization....

Ghada A. Badawi, Rehab M. El-Sayed, Mohamed N. Fawzy · 0 citations
Review Open access Aug 2026

The neuroimmune network in Alzheimer’s and Parkinson’s diseases: from mechanistic insights to biomarker-guided immunotherapies and clinical translation

A three-part biomarker framework, encompassing target engagement (CSF IL-1β, caspase-1), pharmacodynamic responses (neurofilament light chain, ASC specks), and predictive endotyping (T-cell clonality, complement profiles), is proposed to facilitate patient stratification by neuroimmune endotype.

Mohamed N. Fawzy · 0 citations

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