Mohamed H. A. Gadelmawla

Quercetin-mediated selenium nanoparticles protect against hyperthyroidism-induced hepatic injury: Involvement of Nrf2/NF-κB signaling, mitochondrial apoptosis, and iron/heme imbalance.

PURPOSE Hyperthyroidism-associated liver injury represents an important extra-thyroidal complication of thyroid hormone excess, driven by increased metabolic demand and interconnected oxidative, inflammatory, and mitochondrial disturbances. However, the coordinated involvement of Nrf2/NF-κB signaling, apoptosis, and ir...

Ferulic acid-mediated selenium nanoparticles attenuate oxaliplatin-induced renal injury in type 2 diabetic rats via modulation of oxidative stress, SIRT1/HMGB1/TLR4 signaling, endoplasmic reticulum stress, and apoptosis.

BACKGROUND Patients with type 2 diabetes mellitus (T2DM) are susceptible to chemotherapy-induced renal injury because of pre-existing oxidative stress, inflammation, and impaired antioxidant defenses. Ferulic acid-mediated selenium nanoparticles (FA-SeNPs) combine the antioxidant properties of ferulic acid with the bio...

Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil–induced cardiotoxicity using kaempferol-mediated selenium nanoparticles

5-Flurouracil (5-FU) is still considered as one of the most popular antimetabolite chemotherapy drugs to treat a wide variety of solid tumors. Dose limiting toxicity on major organs, especially cardiovascular system limits the therapeutic use of 5-FU. The current paper addresses the cardioprotective effect of green syn...

Kaempferol conjugated selenium nanoparticles mitigate kidney injury from rhabdomyolysis through antioxidant and anti-inflammatory actions via Nrf2/NF-κb pathway.

"Lariocidin and ribosome-targeting lasso peptides as emerging antimicrobial agents against multidrug-resistant bacteria".

pH-Responsive Carboxymethyl Cellulose-Encapsulating Hesperidin–Selenium Nanoparticles Attenuate Paracetamol-Induced Acute Kidney Injury via Keap-1/Nrf2, NF-κB, and Mitochondrial Apoptosis Modulation

Paracetamol overdose is a major cause of drug-induced acute kidney injury (AKI), driven by oxidative stress, inflammation, mitochondrial dysfunction, and tubular apoptosis. This study evaluated the nephroprotective efficacy of pH-responsive carboxymethyl cellulose-encapsulated hesperidin-stabilized selenium nanoparticl...

Rutin-Functionalized Selenium Nanoparticles Attenuate Cisplatin-Induced Cardiohepatic Injury in Rats: Modulation of ER Stress-Related Gene Expression and Mitochondrial Apoptotic Markers

RUT-SeNPs may represent a promising nanoformulation for reducing cisplatin-induced hepato-cardiac toxicity through coordinated modulation of oxidative stress, inflammation, endoplasmic reticulum stress, and apoptosis.