Mobin Mohammadi

Pentoxifylline, as nonselective phosphodiesterase inhibitor, attenuate paraquat-induced hepatic damage: in vivo and molecular docking insights

PTX administration may prevent PQ-induced hepatic damage in mice, potentially by inhibiting free radical formation and molecular docking analysis suggests that PTX may reduce PQ-induced oxidative stress by competitively inhibiting the FAD-binding site of xanthine oxidase, and by engaging a non-active-site region of NADPH oxidase.