Open access
Sep 2026
A single ROSA26 mouse line for robust tdTomato labeling with Cre, FLP, Dre, Vika, SCre, and VCre recombinases.
Maintaining separate reporter lines for diverse site-specific recombinases (SSRs) imposes a major logistical bottleneck in complex genetic modeling. Here, we developed the ROSA26-6R reporter mouse, a single, universal line providing robust tdTomato expression for six distinct SSRs: Cre, FLP, Dre, Vika, SCre, and VCre....
Toshiaki Nakashiba, Takashi Sugiyama, Yoshitaka Yamashita et al.
· Cell Reports Methods · 0 citations