Upregulated ST2L-Dependent IL-33 Signaling in Dermal Fibroblasts Contributes to IL-6 Induction and Skin Fibrosis in Systemic Sclerosis.
Persistent activation of dermal fibroblasts drives progressive skin fibrosis in systemic sclerosis (SSc), a connective tissue disease. However, the mechanisms sustaining fibroblast activation remain incompletely defined. Interleukin-33 (IL-33), an alarmin-like IL-1 family cytokine, signals via the membrane receptor ST2...