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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Mitsuhiro Fujishiro

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2 papers indexed here

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Open access Sep 2026

Bcl-xL Promotes Gastric Tumorigenesis via Apoptosis-Independent Wnt/β-Catenin Activation and PPARγ Suppression.

BACKGROUND AND AIMS The Wnt/β-catenin and YAP pathways cooperatively drive gastrointestinal tumor progression. BCL2L1, a YAP target gene, encodes the anti-apoptotic isoform Bcl-xL, which is highly expressed in multiple cancers, but its role in gastric cancer remains unclear. METHODS We generated Mist1-CreERT; Apcflox...

Y. Oya, J. Arai, Yoku Hayakawa et al. · 0 citations
Sep 2026

Abstract B094: CDK12 inhibition activates cGAS-STING-mediated antitumor immunity and enhances immune checkpoint blockade in basal-like PDAC

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy with limited effective therapies. Using a patient-derived organoid-based drug screen, we identified cyclin-dependent kinase 12 (CDK12) as a promising therapeutic target, particularly in basal-like PDAC. CDK12 is a transcription-associated cycl...

Dosuke Iwadate, Keisuke Yamamoto, Hiroyuki Kato et al. · 0 citations

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